PhD Student – “Targeting Leukemia in Preclinical Models” group

This project aims at uncovering epigenetic vulnerabilities in acute myeloid leukemia (AML) cells and evaluating the efficacy of targeted epigenetic therapy in different in vitro and in vivo leukemia models. We will focus on the epigenetic complexes that cooperate with the oncogene NPM1c. We have previously shown that NPM1c is highly dependent on the MLL histone methyltransferase complex and based on our studies novel targeted therapy approaches are currently in phase II clinical trials (Uckelmann et al. Science 2020). Our recently published study further shows that NPM1c, which was previously been thought to mainly act in the cytoplasm of cancer cells, is present in the nucleus and recruited to chromatin where it directly regulates oncogenic gene expression (Uckelmann et al. Cancer Discovery 2022). In this project we will take a closer look at cooperating partners of NPM1c on chromatin to uncover novel vulnerabilities in AML.

• Excellent scientific environment & dedicated mentoring
• Training in novel cutting edge techniques to study epigenetic mechanisms in leukemia cells
  Collaboration opportunities with national & international world-leading laboratories
• Participation in training and qualification programs of the MSNZ and the Goethe University
• The position (65% - E 13) is initially limited for 3 years with the possibility for extension
• Public transportation ticket for free
• The "Uni-Strolche" - our day nursery (currently there is a waiting list)

We are targeting applicants of all genders and nationalities. Applicants with handicap will be preferred if personal and professional skills are equivalent.